#3849 PERITONEAL DIALYSIS CATHETER LOCK: PREVENTING RELAPSES

Abstract Background and Aims The incidence of peritonitis has markedly decreased in the last decades, nevertheless it remains one main causes catheter removal subsequent dialysis modality change. In long-term severe relapses can lead to peritoneal membrane failure. Some bacteria form biofilms lumen granting them resistance against antibiotics thus being for infection recurrences. To find a viable way avoid or/and eradicate bacterial biofilm catheters given importance infections. Method We present experience our unit coadjuvant treatment dialysis-associated with locks past few years. used two kinds lock depending on isolated germ divided groups. Group I gram-positive staphylococcus group II gram-negative germs, specifically pseudomona. reported 12 cases from which 10 were first episode (epidermidis Aureus) peritonitis. For we locked 350mg daptomycin 7ml saline solution once week without using hours. other 2 pseudomona taurolidine/urokinase during exchange icodextrin twice hours dwell time until 9 archived. Results treated patients (Table 1). Peritonitis was resolved recurrences I. case Methicillin-resistant Staphylococcus aureus involved there no response removed. both their Conclusion study locking seems reduce